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pentobarbital will minimize the level or result of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will minimize the extent or effect of buprenorphine buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will reduce the extent or effect of sipon